NIMH » NIMH Creates Publicly Accessible Resource With Data From Healthy Volunteers

Analysis Spotlight

Finding out wholesome folks will help researchers perceive how the mind works in states of well being and sickness. Though many psychological well being research embrace wholesome contributors as a comparability group, these research usually concentrate on chosen measures related to a sure purposeful area or particular psychological sickness. The Wholesome Analysis Volunteer Research on the Nationwide Institute of Psychological Well being goals to construct a complete, publicly accessible useful resource with a variety of mind and behavioral knowledge from wholesome volunteers.

This useful resource goals to make clear fundamental questions on mind perform and translational questions in regards to the relationship between mind and conduct. Though the examine focuses on wholesome volunteers, the information even have relevance to medical questions on neurobiological, cognitive, and emotional processes related to sure psychological diseases.

The NIMH Wholesome Analysis Volunteer Research is exclusive within the breadth and depth of its measures. All knowledge collected as a part of the examine are anonymized and shared with the analysis neighborhood through the OpenNeuro repository.

Given the effort and time required for participation, wholesome volunteers are recruited from the native Washington, D.C., space. volunteers begin by finishing a web based screening questionnaire wherein they report sure demographic and well being data. Volunteers who meet the examine inclusion standards full an in-person evaluation, together with complete psychological and bodily well being evaluations.

As a part of the psychological well being analysis, they full a psychiatric diagnostic interview, self-report surveys of temper and anxiousness signs, and a cognitive evaluation. For the bodily well being analysis, the examine crew interviews volunteers about their medical historical past and performs a complete bodily evaluation. In addition they assess immune perform, hormone ranges, and different physiological traits.

Importantly, a portion of the wholesome volunteers endure a number of sorts of mind imaging, together with structural and resting state purposeful MRI and diffusion tensor imaging. Some contributors additionally endure magnetoencephalography (MEG) scans whereas performing a collection of cognitive duties, a specific energy of the examine. The MEG duties faucet into a variety of cognitive domains related to psychological diseases, together with consideration, emotion processing, response inhibition, and dealing reminiscence. By combining a number of mind imaging modalities, the examine has the potential to supply distinctive perception into each mind construction and mind perform.

Participant recruitment and knowledge assortment are ongoing. So far, the repository comprises publicly out there knowledge from greater than 1,000 wholesome volunteers, with nearly 300 in-person assessments, greater than 150 MRI scans, and greater than 65 MEG recordings. The examine crew will launch knowledge from newly enrolled volunteers in waves, permitting researchers to carry out reliability and replicability analyses throughout totally different knowledge releases.

To be taught extra, go to the NIMH Wholesome Analysis Volunteer webpage.


Nugent, A. C., Thomas, A. G., Mahoney, M., Gibbons, A., Smith, J. T., Charles, A. J., Shaw, J. S., Stout, J. D., Namyst, A. M., Basavaraj, A., Earl, E., Riddle, T., Snow, J., Japee, S., Pavletic, A. J., Sinclair, S., Roopchansingh, V., Bandettini, P. A., & Chung, J. (2022). The NIMH intramural wholesome volunteer dataset: A complete MEG, MRI, and behavioral useful resource. Scientific Information, 9, Article 518.

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